11/9/2023 0 Comments Running an istat abg sampleThus, blood gas testing for acid-base analysis has become an indispensable tool in the management and prognostication of critically ill patients (Hopper et al. The resultant pH is due to a complex balance between various intra- and extracellular buffer systems, plasma ion concentrations and functional interaction of the respiratory and renal systems (Hopper et al. The body strives to maintain blood pH within a narrow range in order to optimise functioning of the cardiovascular and nervous systems as well as miscellaneous metabolic functions (Kules et al. Keywords: pre-analytical phase, analytical phase, post-analytical phase, analytical errors, blood pH, Henderson-Hasselbalch, physicochemical approach, semiquantitative approach The potential sources of error during the various phases are reviewed. Furthermore, errors occurring in the measurements of electrolytes and lactate will result in incorrect interpretations if the physicochemical and semiquantitative approaches are applied. Errors in the measurement of the carbon dioxide tension (from which bicarbonate concentration and base excess are calculated) will introduce error into all three methods of acid-base interpretation. Errors occurring during the prior phases will be amplified. Some of the approaches to acid-base interpretation require extensive post-analytical calculations, thus lending themselves to error. The post-analytical phase mainly describes interpretation of the results. Common analytical errors are related to substances confounding analyte measurements. The analytical phase outlines processes within the analyser. Pre-analytical errors include entrainment of air bubbles into the sample and delays between sampling and analysis, both of which cause inaccurate measurement of oxygen and carbon dioxide tensions. Most errors occur during the pre-analytical phase. The pre-analytical phase incorporates steps in obtaining the sample, thus sources of pre-analytical error are related to operator technique. However, blood gas analysis is prone to error during the pre-analytical, analytical and post-analytical phases of the laboratory process. Common methods of acid-base interpretation in veterinary science are the traditional approach, the physicochemical approach and the semiquantitative approach. Blood gas analysis is thus essential in the diagnosis and management of disorders affecting blood pH. This narrow pH range is maintained via the interactions of various buffer systems. Preservation of blood pH within a narrow range is essential to optimal physiological function. IISection of Anaesthesia and Critical Care, Valley Farm Animal Hospital, South Africa IDepartment of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, South Africa Sources of error in acid-base analysis from a blood gas analyser result: a narrative reviewĪR Kadwa I, II JF Grace I, II GE Zeiler I, II
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |